In the southeast part the capital and main port of the island is located beside a rocky hill, known as Karpathos or Pigadia whose name comes from the many wells that existed in the region. It is a relatively new city with about 2000 inhabitants and It is built in the same place as the ancient town Potideo. Pigadia is a modern state and the buildings do not follow any traditional architecture nonetheless the harbor and the marina with its colorful boats ensure a happy first impression. Touring around the town visitors will meet beautiful pictures that combine the island tradition with modern comforts.

Among the important sites are the remains of paleochristianic basilica of Saint Fotini on the coastal road. Cave of Posidon one of Karpathos natural sites is located in location Mili, carved into rock temple was dedicated to Poseidon or Aphrodite.

Pigadia extended clean beaches attracts many visitors in the summer who can enjoy swimming with all the modern comforts. Visitors can approach other isolated beaches, closed gulfs and ports by car or by boat from the main harbor.

The capital is the most organized tourist region in the island with hotels and rooms to let and as the sun goes down there are a lot of bars and clubs that will entertain visitors until next morning.